In order to remain viable, cancer cells require the primary fuels glucose and glutamine, to compensate for Oxidative Phosphorylation insufficiency.
Damage to mitochondrial concentrations of diphosphatidylglycerol and structurally abnormal cristae, induce downstream overexpression of oncogenes and inactivation of tumor-suppressor genes, which further enhance abnormal energy metabolism in cancer.
To date, no evidence has demonstrated the growth of any tumor cells, including Cancer Stem Cells, can occur with the deprivation of the fermentable fuels, glucose and glutamine.
Notably, any given tumor model's degree of malignancy can be directly correlated with significantly lower mitochondria and lower total respiratory capacity in tumor cells.
Furthermore, the tumor microenvironment is characterized by low
pH, hypoxia, entropy, pressure and deformation, increased temperature, stroma, altered rotation of cytoplasmic water, and downregulated proton gradient potential.
Hence, interventions which directly address the fundamental biology of disease, offer a sustainable and non-toxic method for managing cancer, longitudinally.
